| Objective To evaluate the efficacy and safety of gabapentin in preemptive analgesia for hysterectomy after general anesthesia. Methods PubMed, Cochrane, Embase, Ovid, Springer Link, Web of Science, CNKI, Wanfang and Weipu databases were searched for randomized placebo-controlled trials involving the efficacy of gabapentin for preemptive analgesia published from 2000 to 2016. The methodological quality of the included randomized controlled trial (RCT) was assessed and the data were extracted according to the Cochrane Handbook. The meta-analysis was performed using the RevMan 5.3 software. Results A total of 10 RCTs involving 609 patients were included. Compared with the control group, there was a significant decrease in 24-hour cumulative narcotic consumption at 24 hours when gabapentin was administered before surgery (WMD=-8.83 mg, 95%CI -12.70－-497, P<0.001), there was no significant decrease in VAS score in preemptive analgesia group (WMD=-7.70 mm, 95%CI -18.22－2.82, P=0.15). Compared with the control group, the rate of vomiting was less in the gabapentin group (RR=0.49, 95%CI 0.35－0.69, P<0.001). Compared with the placebo group, there was no significant decrease in nausea (RR=0.73, 95%CI 0.45－1.17, P=0.19) and somnolence (RR=2.08, 95%CI 0.62－6.92, P=0.23). Conclusion Preemptive administration of gabapentin is effective in decreasing accumulation of opium and vomiting. |
