文章摘要
术前输注头孢呋辛钠后不同靶控浓度丙泊酚对妇科手术患者心室复极的影响
Effects of target-controlled infusion of propofol with different concentrations on ventricular repolarization after preoperative infusion of cefuroxime sodium in patients undergoing gynecologic opera-tion
  
DOI：10.12089/jca.2016.12.008
中文关键词: 头孢呋辛钠  丙泊酚  T波峰值至终点时间  QT间期
英文关键词: Cefuroxime sodium  Propofol  Tp-e interval  QT interval
基金项目:贵阳市科技计划项目(筑科合同[2015001]社引号)
作者单位
雷涓 贵州省麻醉学专业学位研究生工作站,贵州医科大学麻醉学院,贵阳市,550004 
高鸿 贵州医科大学附属医院麻醉科 
刘艳秋 贵州医科大学附属医院麻醉科 
文春雷 贵州省麻醉学专业学位研究生工作站,贵州医科大学麻醉学院,贵阳市,550004 
张凯强 贵州省麻醉学专业学位研究生工作站,贵州医科大学麻醉学院,贵阳市,550004 
李惠 贵州省麻醉学专业学位研究生工作站,贵州医科大学麻醉学院,贵阳市,550004 
摘要点击次数: 3400
全文下载次数: 1878
中文摘要:
      目的：观察术前预防性输注头孢呋辛钠后不同靶控浓度丙泊酚对妇科手术患者心室复极的影响。方法选择择期妇科手术患者59例,年龄18~65岁,ASA Ⅰ或Ⅱ级,采用随机数字表法分为三组。入室补液并静滴头孢呋辛钠2.5 g(溶于100 ml 生理盐水中)后,分别泵注丙泊酚血浆靶控浓度为2μg/ml(P2组,n =20)、3μg/ml(P3组,n =19)、4μg/ml(P4组,n =20)。分别在抗生素输注前(T0)、抗生素输注完毕(T1)、及丙泊酚达到靶控浓度时(T2),测量并计算 QT 间期、QTc 间期、T 波峰值至终点时间(Tp-e 间期)及 Tp-e/QT。结果与 T0时比较,T1时 P4组 QTc 间期[(469.9±34.0)ms vs.(451.2±24.9)ms]、Tp-e 间期[(107±25)ms vs.(94±20)ms]、Tp-e/QT (0.260±0.058 vs.0.236±0.043)明显延长(P <0.05)；与 T1时比较,T2时 P2组[(437.4±24.4)ms vs.(453.3±28.0)ms]和 P4组[(438.8±29.9)ms vs.(469.9±34.0)ms]QTc 间期明显缩短(P <0.05)。结论丙泊酚可改善头孢呋辛钠引起的心室复极不均一性。
英文摘要:
      Objective To investigate the effects of target-controlled confusion of propofol with different concentrations on ventricular repolarization after prophylactic infusion of cefuroxime sodium. Methods Sixty ASA physical status Ⅰ or Ⅱ female patients,aged 18-65 years,undergoing elective gynecological surgery were randomly divided into three groups:group P2 (n =20)with TCI 2 μg/ml, group P3 (n =1 9)with TCI 3 μg/ml and group P4 (n =20)with TCI 4 μg/ml.Firstly,they were re-hydrated;secondly,the patients in groups P2,P3 and P4 were intravenous infused with cefuroxime sodium 2.5 g (in 100 ml normal saline)and then target-controlled infused of propofol 2 μg/ml,3μg/ml and 4 μg/ml in target plasma concentration,respectively.At three pionts of time:after rehy-dration before intravenous antibiotics (T0 ),after intravenous antibiotics before TCI of propofol (T1 ), after TCI of propofol (T2 ),QT interval,QTc interval,Tp-e interval were measured and recorded, respectively.Results Compared with T0 ,QTc [(469.9 ± 34.0)ms vs.(451.2 ± 24.9)ms],Tp-e [(107±25)ms vs.(94±20)ms]and Tp-e/QT (0.260±0.058 vs.0.236±0.043)in group P4 were sig-nificantly prolonged at T1 (P < 0.05 ).Compared with T1 ,QTc of groups P2 [(437.4 ± 24.4)ms vs. (453.3±28.0)ms]and P4 [(438.8±29.9)ms vs.(469.9±34.0)ms]were shortened significantly at T2 (P <0.05).Conclusion Propofol could improve ventricular reporlarization heterogeneity caused by cefu-roxime sodium.
查看全文   查看/发表评论  下载PDF阅读器
关闭