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| 布比卡因脂质体用于心脏手术后镇痛的研究进展 |
| Advances in use of liposomal bupivacaine for postoperative analgesia after cardiac surgery |
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| DOI：10.12089/jca.2026.01.014 |
| 中文关键词: 术后镇痛 布比卡因脂质体 心脏手术 |
| 英文关键词: Postoperative analgesia Liposomal bupivacaine Cardiac surgery |
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| 中文摘要: |
| 术后镇痛是心脏手术围术期多学科协作诊疗中的关键环节，镇痛不足不仅影响患者术后康复质量、增加并发症发生率，还可能增加医疗资源消耗。传统阿片类药物主导的镇痛模式，因存在呼吸抑制、胃肠功能障碍等不良反应，日益难以满足加速术后康复理念的需求。近年来，随着多模式镇痛技术的发展和新型镇痛方法的涌现，布比卡因脂质体作为一种新型长效局部麻醉药在临床应用，为优化心脏手术后镇痛策略提供了新的可能。本文基于循证医学证据，从作用机制、安全性以及在心脏手术后镇痛中的具体应用三个方面系统综述了布比卡因脂质体在心脏手术后镇痛的研究进展，并对其临床应用前景进行总结。 |
| 英文摘要: |
| Postoperative analgesia is a critical component of the perioperative multidisciplinary collaboration for cardiac surgery. Inadequate analgesia not only compromises the quality of postoperative recovery and increases the risk of complications but may also escalates healthcare resource utilization. The traditional opioid-centric analgesic paradigm, with its associated adverse effects such as respiratory depression and gastrointestinal dysfunction, is increasingly at odds with the demands of enhanced recovery after surgery (ERAS). In recent years, the development of multimodal analgesia techniques and novel analgesic approaches has provided new opportunities to optimize postoperative pain management strategies. Among these, liposomal bupivacaine, a novel long-acting local anesthetic, has emerged as a promising option for improving postoperative analgesia in cardiac surgery. This article based on evidence from evidence-based medicine, systematically reviews the latest research progress of liposomal bupivacaine in the field of postoperative analgesia after cardiac surgery from three aspects: mechanism of action, safety, and application in postoperative analgesia after cardiac surgery, and summarizes and reflects on its clinical application prospects. |
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